Research and Publications

Research Interests:

Heart damage in mammals is generally considered to result in formation of a scar, whereas some lower vertebrates can completely regenerate their hearts following an intermediate and reversible state of fibrosis. The Senyo group is interested in understanding fundamental mechanisms regulating the differential regenerative response observed across species, across ages, and in distinct forms of injury. Toward this aim, Dr. Senyo performs comparative studies using mammalian model systems, including human stem cell. Through collaboration and in-house method development, the Senyo group seeks to develop new treatments for human disease and to foster a community of new scientists in academia and the private sector.

Recent Publications:

• Loss of white adipose hyperplastic potential is associated with enhanced susceptibility to insulin resistance; SM Kim, M Lun, M Wang, SE Senyo, C Guillermier, P Patwari, ML Steinhauser – Cell metabolism 20 (6), 1049-1058
• Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation; SE Senyo, RT Lee, B Kühn – Stem cell research, 2014
• Mammalian heart renewal by pre-existing cardiomyocytes; SE Senyo, ML Steinhauser, CL Pizzimenti, VK Yang, L Cai, M Wang, T-D Wu, J-L Guerquin-Kern, CP Lechene, RT Lee – Nature, 2013
• Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism; ML Steinhauser, AP Bailey, SE Senyo, C Guillermier, TS Perlstein, AP Gould, RT Lee, CP Lechene – Nature, 2012