Engineering Platforms to Study Cardiovascular Disease
Most cells in the body exhibit an intimate relationship with the surrounding locale, which is referred to as the microenvironment. The microenvironment includes protein and sugar (fixed and mobile), gas, stiffness, physical motion, ions, and other cells to name a few. The complexity of the systems increases with dynamic changes with normal life and disease.
We are developing integrated microsystems to tightly control the microenvironment of cells. Microfabrication, polymer chemistry, and molecular biology are all employed to establish a model system of our tissue of interest, the heart, to investigate parameters that influence disease and tissue repair.